Cardiology
Long QT Syndrome (LQTS) - Expanded Panel
Overview
Test Name
Test Code
Test Category
Test Subcategory
Disease(s) Targeted
Who Is The Test For?
Test Approach
Whole exome sequencing (WES) with in silico gene panel analysis
No. of Genes
Panel Content
Mitochondrial Genome Included In The Analysis
Deliverables
Clinical Report (Download a sample report here)
Turnaround Time
~3-6 weeks*
Specimen Requirements
For detailed information about the sample requirements, please consult our clinical sample requirements page.
Alternative Panels Available
This is the expanded panel for Long QT Syndrome (LQTS). We also offer a core panel which includes 6 less genes genes (11 genes in total). See test details for the Long QT Syndrome (LQTS)- Core Panel.
About Long QT Syndrome (LQTS)
Long QT syndrome (LQTS) is an inherited heart rhythm problem, characterised by QT prolongation and T wave abnormalities on an ECG that is associated with tachyarrhythmias, most typically the ventricular tachycardia “torsade de pointes” (TdP). LQTS is a panethnic disorder with an estimated prevalence of around 1 in 2,500.
LQTS mainly follows an autosomal dominant pattern of inheritance, though there are also autosomal recessive forms. LQTS associated with biallelic pathogenic variants (in genes associated with autosomal dominant LQTS) or heterozygosity for pathogenic variants in two different genes (i.e., digenic pathogenic variants) is generally associated with a more severe phenotype with longer QTc interval and a higher incidence of cardiac events.
Pathogenic variants in KCNH2, KCNQ1, and SCN5A genes account for 90% of individuals with an identified molecular cause of LQTS.
Gene Panel Workflow
Order a test using our clinical portal
Preview Documents