Cardiology
Short QT Syndrome (SQTS) Panel
Overview
Test Name
Test Code
Test Category
Test Subcategory
Disease(s) Targeted
Who Is The Test For?
Test Approach
Whole exome sequencing (WES) with in silico gene panel analysis
No. of Genes
Panel Content
Mitochondrial Genome Included In The Analysis
Deliverables
Clinical Report (Download a sample report here)
Turnaround Time
~3-6 weeks*
Specimen Requirements
For detailed information about the sample requirements, please consult our clinical sample requirements page.
About Short QT Syndrome (SQTS)
Short QT syndrome (SQTS) is an inherited cardiac channelopathy characterised by an abnormally short QT interval and increased risk for atrial and ventricular arrhythmias.
Studies suggest a prevalence between 0.02% and 0.1% in adults while in paediatric population the prevalence is 0.05%. Lethal events may occur in both sexes, but a slight male predominance seems to exist.
SQTS is caused by pathogenic variants in the genes that encode proteins that compose ion channels, which are responsible for the currents in the heart. Gain-of-function variants in genes encoding potassium channels (KCNH2, KCNQ1 and KCNJ2) and loss-of-function variants in genes for calcium channels (CACNA1C, CACNB2) are frequently identified. SQTS is inherited in an autosomal dominant manner, such that first-degree family members have a 50% chance of inheriting the disorder.
Gene Panel Workflow
Order a test using our clinical portal
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